Mycophenolic acid (10 mM)

Background

Mycophenolic acid (MPA), a class of antibiotics/antibacterial drugs derived from Penicillium stoloniferum and similar strains, can block the synthesis of purine nucleotides in vivo by inhibiting the action of hypoxanthine nucleotide dehydrogenase, preventing the division of T cells and lymphocytes and the formation of antibodies in B cells, thus having the function of immunosuppressive factor, and is used in molecular biology to screen cells containing xanthine guanine phosphoribosyltransferase gene.
Mycophenolic acid is also a kind of potent non-competitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). In recent years, with the in-depth study of MPA, people found that MPA showed a variety of new pharmacological effects. Studies have shown that MPA can inhibit the proliferation of tumor cells such as leukemia, lymphoma, pancreatic cancer, non-small cell lung cancer and colon cancer. In addition, it can also induce the differentiation or apoptosis of a variety of tumor cell lines including cervical cancer, breast cancer, prostate cancer, melanoma, leukemia and glioblastoma.

Ingredient Statement

Matters Need Attention

1. This product is only used for scientific research or further research, not for diagnosis and treatment.
2. This product was sterilized by 0.1 μm filtration and can be used directly after melting.
3. It is necessary to pay attention to the aseptic operation and avoid the contamination.
4. Before using, the product should be thawed at 2-8℃ and shaken thoroughly

repeated freeze-thaw cycles are not advised.
5. If precipitation happens after thawing, the contents can be resuspended by pipetting or vortex mixing. After incubating the solution at 37℃ for 20 to 30 minutes or letting it stand at room temperature for about an hour, check to see if the precipitate dissolves as intended. If the product dissolves completely, it can be used as usual.
6. This product is a concentrated solution and should be diluted prior to use as required.
7. The product should be used within a month if stored regularly at 2-8℃. Keep in a frozen state at -5~-20℃ for extended storage. Long-term storage at room temperature or between 2-8℃ is not recommended. When lesser amounts are required, aliquoting is advised to prevent repeated freeze-thaw cycles.

System Certification

GMP Production and Quality System
The company complies with cGMP requirements, holds the NMPA medical device registration certificate, and is certified under ISO 13485 and ISO 9001 standards. Among its products, the company's Mycophenolic acid (10 mM) complies with ISO 9001.